Week 2 Fundamentals of Immunology Quiz Death by Friendly Fire

Week 2 Fundamentals of Immunology Quiz Death by Friendly Fire

Quiz 2



Question 1
1. PAMPs and DAMPs differ in that the ________.
  • PAMPs are derived directly from pathogens and the DAMPs from damaged self-tissue


  • PAMPs trigger the activation of IL-1, DAMPs do not.


  • PAMPs increased the inflammatory response, DAMPs lower it


  • DAMPs activate complement, PAMPs do not


  • PAMPs provide a better measure of the virulence and lethality of an infection


Question 2
2. Inflammatory chemokines bind to ________ receptors, which then activate ________.
  • seven-span; G proteins


  • seven-span; apoptosis


  • Ig; G proteins


  • Ig; integrins


  • tumor necrosis factor; apoptosis


  • tumor necrosis factor; integrins


Question 3
3. Based on its function, where would you be most likely to see HEV?
  • as part of the blood-brain barrier


  • facilitating oxygen exchange in the lungs


  • in vessels leading to lymph nodes, promoting extravasation of T cells


  • in the thymus, promoting exit of γδ cells


  • close to inflamed tissue, directing neutrophils and B cells to the infection


Question 4
4. The black pointer indicates an interaction that most directly leads to _________.
  • activation of NFAT in the neutrophil


  • stimulation of a toll-like receptor


  • shape changes in the neutrophil that cause it to insert between two endothelial cells


  • activation of G protein in the neutrophil


  • the neutrophil briefly adhering to the endothelium


Question 5
5. Which of the following CANNOT trigger assembly of the inflammasome
  • LPS


  • viral and bacterial DNA


  • alum


  • β-amyloid


  • UV light


  • Any of these things may trigger assembly and thus inflammation.


Question 6
6. In this picture of the inflammasome, the pointer labeled ___ indicates the site that recognized the danger signal, the arrow labeled _____ indicates the region most responsible for assembly of the overall heptamer and regions labeled _____ indicates the domain that clips the inactive IL-1 precursor, activating it.
  • I, II, III


  • I, III, II


  • II, I, III


  • II, III, I


  • III, I, II


  • III, II, I


Question 7
7. This compound is a __________ important in producing _________.
  • lipid; clotting and clot removal


  • lipid; pain and endothelial permeability


  • peptide; clotting and clot removal


  • peptide; pain and endothelial permeability


Question 8
8. Lipoxygenases are important in the production of ________ and cyclo-oxygenases are important in producing ____________.
  • leukotrienes; prostaglandins


  • leukotrienes; PAF


  • prostaglandins; leukotrienes


  • prostaglandins, PAF


  • PAF; prostaglandins


  • PAF; leukotrienes


Question 9
9. The hydrolysis shown here by the yellow line is most directly triggered by the action of _______.
  • Hageman’s factor


  • thrombin


  • kallikrein


  • cyclo-oxygenases


  • GTP produce by G proteins


Question 10
10. Pus formation largely results from the accumulation of the remains of dead and dying ________.
  • neutrophils


  • macrophages


  • epithelial cells


  • sentinel dendritic cells


  • red blood cells and platelets
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