Compound efficacy contributes for about 1/3 of the failed cases in small molecule drug discovery. Which of the following statements defines the meaning of Efficacy?
Compound binds strongly on the protein target
Compound binds on the protein target, blocks its function in the body but does not have the expected therapeutic/treating effect.
Compound binds on its target and results in the treatment/cure of the pathological condition and delivers the expected therapeutic results